Thrombopoietin receptor agonists for the treatment of inherited thrombocytopenia
نویسندگان
چکیده
منابع مشابه
Use of Thrombopoietin Receptor Agonists in Childhood Immune Thrombocytopenia
Most children with immune thrombocytopenia (ITP) will have spontaneous remission regardless of therapy, while about 20% will go on to have chronic ITP. In those children with chronic ITP who need treatment, standard therapies for acute ITP may have adverse effects that complicate their long-term use. Thus, alternative treatment options are needed for children with chronic ITP. Thrombopoietin re...
متن کاملWill thrombopoietin receptor agonists become a treatment option for pediatric chronic immune thrombocytopenia in the future?
2015 Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by a low platelet count and increased bleeding tendency. Most children with ITP spontaneously recover. However, children with severe bleeding may require treatment. Traditional treatments such as corticosteroids or splenectomy are often associated with increased risks of infections. Currently, there is evidence that plat...
متن کاملTreatment of immune thrombocytopenia in adults: the role of thrombopoietin-receptor agonists.
The pathophysiology, classification, epidemiology, and treatment of immune thrombocytopenia (ITP) have witnessed great progresses in the last decade and are briefly addressed here. After more than 5 years of use in clinical practice, a new class of drugs acting as thrombopoietin-receptor (TPO-R) agonists is gaining a more definite role in the treatment of primary ITP in adults. The two currentl...
متن کاملThe biology of thrombopoietin and thrombopoietin receptor agonists.
Thrombopoietin (TPO) is the major physiological regulator of platelet production. TPO binds the TPO receptor, activates JAK and STAT pathways, thus stimulating megakaryocyte growth and platelet production. There is no "sensor" of the platelet count; rather TPO is produced in the liver at a constant rate and cleared by TPO receptors on platelets. TPO levels are inversely proportional to the rate...
متن کاملClinical indications for thrombopoietin and thrombopoietin-receptor agonists.
Thrombocytopenia is a common hematologic disorder. Stimulation of thrombopoiesis may reduce the risk for thrombocytopenia-induced bleeding, prevent severe thrombocytopenia, and reduce the need for platelet transfusion. The key cytokine is thrombopoietin (TPO). It regulates proliferation and maturation of megakaryocytes as well as platelet production. TPO is synthesized in the liver. Development...
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ژورنال
عنوان ژورنال: Haematologica
سال: 2020
ISSN: 0390-6078,1592-8721
DOI: 10.3324/haematol.2019.241786